The villa for Dr. Müller was built on a plot between the streets Střešovicka and Nad hradním vodojem. The pentagonal plot has a total area of 1,270 m2 (of which 555 m2 are built on and 715 m2 are garden), and runs down an 11m north-facing slope. This sloping terrain was a considerable disadvantage when it came to erecting a building. The highest part of the plot, adjacent to Nad hradním vodojemem and giving access to the villa, is at an altitude of 308.97m and is conspicuously higher than Prague Castle. The exceptionally beautiful views across the valley of the Vltava with Trója Château in the distance, the clear horizon and an interesting vista of St Vitus' Cathedral, however, outweigh the disadvantage of the slope.
The new building was situated in such a way as to be as far as possible from the neighbouring buildings. The villa is reached via a public stair which was built at the same time as the villa itself, and which was partly financed by Dr. Müller. The steps link the lower lying Střešovicka ul. with Nad hradním vodojemem.